【临床试验招募】阿比特龙强的松联合雄激素去除法治疗前列腺癌临床研究
发布:2019-03-01 13:21:49
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题目和背景信息


 适应症: 激素敏感的高危转移性前列腺癌
 试验通俗题目: 阿比特龙强的松联合雄激素去除法治疗前列腺癌临床研究
 试验专业题目: 初诊激素未治高危转移前列腺癌醋酸阿比特龙联合泼尼松及雄激素去除疗法对比雄激素去除疗法随机双盲对照研究
 试验方案编号: 212082PCR3011-INT-4
 临床申请受理号: 企业选择不公示
 药物名称: 醋酸阿比特龙
 药物类型: 化学药物

   

临床试验信息


 1、试验目的
主要目的是确定在改善存在高危预后因素的mHNPC 受试者的生存期方面,醋酸阿比特龙与低剂量强的松和雄激素去除疗法(ADT)联合治疗是否优于ADT 单独治疗。次要目的是评估醋酸阿比特龙加上低剂量强的松和ADT 相比ADT 单独治疗的临床相关改善情况以及安全性,确定microRNA(miRNA)和mRNA 表达谱,以预测阿比特龙的疗效和耐药性。
 2、试验设计(单选)
  试验分类: 安全性和有效性
  试验分期: III期
  设计类型: 平行分组
  随机化: 随机化
  盲法: 双盲
  试验范围: 国际多中心试验
 3、受试者信息
年龄   18岁(最小年龄)至 N/A岁(最大年龄)
性别   男
健康受试者   无
入选标准
1 愿意且能够提供书面知情同意
2 年龄为 18 岁及以上的男性
3 在随机入组之前 3 个月内新诊断的转移性前列腺癌,该前列腺癌必须是经组织学或细胞学确认的腺癌,没有神经内分泌分化且非小细胞癌
4 有文件证实的远端转移,如骨扫描结果为阳性或CT/MRI 结果中提示的转移灶
5 根据修订要求更改的标准,满足以下3个高危预后因素中的至少两个:Gleason 评分≥8,骨扫描中存在3 处或更多处病灶, CT 或 MRI 结果提示存在可测量的内脏转移(淋巴结转移除外)(RECIST 1.1) (X附录 1X)
6 ECOG体能评分为 0、1 或 2 (X附录 1X2)
7 根据修订要求更改的标准,适当的血液学、肝脏和肾脏功能指标:不依赖于输血的血红蛋白9.0 g/dL,中性粒细胞1.5 x 109/L,血小板100 x 109/L,总胆红素 正常值上限(ULN)的 1.5 倍[有吉尔伯特氏病(Gilbert’s disease)病史的受试者,其总胆红素不超过 ULN 的 10 倍],丙氨酸(ALT)和天冬氨酸(AST)转氨酶 ULN 的 2.5 倍,血清肌酐 < ULN 的 1.5 倍或计算的肌酐清除率 50 mL/min,血清钾 3.5 mM,血清白蛋白 ≥ 3.0 g/dL
8 能够吞服研究药物
9 如果与具有生育能力的女性发生性行为,同意使用避孕套和其他有效的避孕方法,如果与孕妇发生性行为,同意使用避孕套
排除标准
1 活动性感染或强的松禁忌使用的其它医疗情况
2 需要皮质类固醇的全身剂量大于每天5 mg强的松的的任何慢性疾病
3 病理学符合前列腺小细胞癌
4 已知的脑转移
5 根据修订要求更改的标准,针对转移性前列腺癌的任何既往药物疗法、放射疗法或手术。以下情况例外:在第1周期第1天之前,最长 3 个月的 ADT 治疗(LHRH 激动剂或睾丸切除术)伴有或未伴有抗雄激素药物是允许的(正在接受LHRH激动剂的受试者获准在疗程1第1天之后的最初2周内使用抗雄激素治疗,但禁止任何超出此范围的使用)。受试者可以接受一个疗程的姑息性放疗或手术治疗,以治疗转移性疾病导致的症状(例如,近迫性脊髓压迫症或阻塞症状),前提是在第1周期第1天之前的至少28天以上施行。与这些程序有关的所有不良事件必须在第1周期第1天之前缓解为1级
6 未得到控制的高血压(收缩压 ≥160 mmHg或舒张压 ≥95 mmHg)。只要血压通过降压治疗得到控制,有高血压病史的受试者可以入选
7 根据修订要求更改的标准,活动性或有症状的病毒性肝炎或慢性肝病,继发于肝功能障碍的腹水或出血性疾病
8 肾上腺功能不全
9 根据修订要求更改的标准,有临床意义的心脏病,有在过去 6 个月内发生心肌梗塞,或动脉血栓性事件或者有心力衰竭病史,严重或不稳定型心绞痛,或纽约心脏协会(New York Heart Association, NYHA)II-IV 级心脏病
10 修订改变的标准,心房颤动;或需要药物治疗的其它心律失常
11 其它恶性肿瘤(5 年内),非黑素瘤皮肤癌除外
12 在第 1 个周期第 1 天前的 28天内接受研究治疗或有创手术(不包括手术去势),或目前已在参与一项研究
13 根据研究者判断,参与研究会增加受试者风险,可能混淆研究结果,或妨碍受试者参与本研究的任何情况或处境
目标入组人数   国际多中心试验:总体1200人, 中国150人;
实际入组人数   登记人暂未填写该信息
 4、试验分组
试验药
序号 名称 用法
1 醋酸阿比特龙 片剂;规格250mg/片; 1000 mg 空腹口服,一天1次,用药时程:服用至疾病进展,死亡,不可耐受的毒性或撤回知情同意。
对照药
序号 名称 用法
1 安慰剂 片剂;规格250mg/片; 1000 mg 空腹口服,一天1次,用药时程:用药时程:服用至疾病进展,死亡,不可耐受的毒性或撤回知情同意
 5、终点指标
主要终点指标及评价时间
序号 指标 评价时间 终点指标选择
1 总生存期,定义为从随机入组至任何原因导致死亡的天数 将在观察到852起事件时进行最终分析。计划在观察到所需事件总数(852起)的50%(426起事件)以及65%(554起事件)之后分别为这项研究进行两项OS的中期分析 有效性指标
2 根据前列腺癌工作组2(PCWG2)和RECIST 1.1,共同主要终点rPFS定义为自随机分配至出现影像学进展或因任何原因而死亡的时间 将在观察到852起事件时进行最终分析。计划在观察到所需事件总数(852起)的50%(426起事件)以及65%(554起事件)之后分别为这项研究进行两项OS的中期分析 有效性指标
次要终点指标及评价时间
序号 指标 评价时间 终点指标选择
1 至下次骨骼相关事件(下述一种)的时间: (1)临床骨折 (2)脊髓压迫症 (3)姑息性骨放疗 (4)骨手术 将在观察到852起事件时进行最终分析。计划在观察到所需事件总数(852起)的50%(426起事件)以及65%(554起事件)之后分别为这项研究进行两项OS的中期分析 有效性指标+安全性指标
2 至PSA 进展时间(根据 PCWG2 标准) 将在观察到852起事件时进行最终分析。计划在观察到所需事件总数(852起)的50%(426起事件)以及65%(554起事件)之后分别为这项研究进行两项OS的中期分析 有效性指标+安全性指标
3 至下次后续前列腺癌治疗的时间 将在观察到852起事件时进行最终分析。计划在观察到所需事件总数(852起)的50%(426起事件)以及65%(554起事件)之后分别为这项研究进行两项OS的中期分析 有效性指标+安全性指标
4 开始化疗的时间 将在观察到852起事件时进行最终分析。计划在观察到所需事件总数(852起)的50%(426起事件)以及65%(554起事件)之后分别为这项研究进行两项OS的中期分析 有效性指标+安全性指标
5 疼痛测量(至疼痛进展时间) 将在观察到852起事件时进行最终分析。计划在观察到所需事件总数(852起)的50%(426起事件)以及65%(554起事件)之后分别为这项研究进行两项OS的中期分析 有效性指标+安全性指标
 6、数据安全监察委员会(DMC):    有
 7、为受试者购买试验伤害保险:   有

    
  研究者信息
 

1、主要研究者信息
姓名 Karim Fizazi 职称 MD
电话 011-33-014-211-6441 Email karim.fizazi@igr.fr
邮政地址 114 rue Edouard Vaillant service d'oncologie médicale VILLEJUIF 邮编 94805
单位名称 INSTITUT GUSTAVE ROUSSY
2、各参加机构信息
序号 机构名称 主要研究者 国家 省(州) 城市
1 INSTITUT GUSTAVE ROUSSY Karim Fizazi France Villejuif Cedex Villejuif Cedex
2 上海华山医院 丁强 中国 上海 上海
3 上海交通大学医学院附属仁济医院 黄翼然 中国 上海 上海
4 中国医学科学院北京协和医院 李汉忠 中国 北京 北京
5 北京大学第一医院 金杰 中国 北京 北京
6 中国医学科学院肿瘤医院 李长岭 中国 北京 北京
7 北京医院 万奔 中国 北京 北京
8 首都医科大学附属北京友谊医院 田野 中国 北京 北京
9 中山大学肿瘤防治中心 周芳坚 中国 广东 广州
10 广州市第一人民医院 谢克基 中国 广东 广州
11 天津市肿瘤医院 姚欣 中国 天津 天津
12 华中科技大学同济医学院附属同济医院 叶章群 中国 湖北 武汉
13 浙江大学医学院附属第一医院 谢立平 中国 浙江 杭州
14 浙江大学医学院附属第二医院 杜传军 中国 浙江 杭州
15 江苏省肿瘤医院 邹青 中国 江苏 南京
16 西南医院 陈志文 中国 重庆 重庆
17 四川省人民医院 邱明星 中国 四川 成都
18 北京大学首钢医院 那彦群 中国 北京 北京
19 上海长海医院 孙颖浩 中国 上海 上海
20 上海华东医院 孙忠全 中国 上海 上海
21 苏州大学附属第二医院 薛波新 中国 江苏 苏州
22 北京大学第三医院 马潞林 中国 北京 北京
23 HOSPITAL BRITANICO DE BUENOS AIRES-UROLOGIA KORBENFELD ERNESTO Argentina NA Buenos Aires
24 CENTRO ONCOLOGICO DE ROSARIO FEIN LUIS ENRIQUE, M.D Argentina SANTA FE ROSARIO
25 Hospital Privado de Cordoba METREBIAN Sergio Victorio Argentina Cordoba Cordoba
26 CENTRO ONCOLOGICO RIOJANO INTEGRAL CORI KAEN LUIS ALBERTO Argentina La Rioja La Rioja
27 SANATORIA GüEMES STANELONI Esteban Argentina Buenos Aires Buenos Aires
28 HOSPITAL MILITAR CENTRAL ¨CIR. MY. DR. COSME ARGERICH BATAGELJ EMILIO JOSE, MD Argentina Buenos Aires Buenos Aires
29 INSTITUTO DAMIC PILNIK Norma Graciela, MD Argentina Córdoba Córdoba
30 Instituto Urologico Buenos Aires ALEJANDRO FAVIO, MD Argentina SANTA FE Buenos Aires
31 Western Hospital Wong Shirley Australia Adelaide Adelaide
32 PRINCE OF WALES HOSPITAL HOVEY ELIZABETH, M.D. Australia Randwick Randwick
33 LIVERPOOL HOSPITAL Chua Wei Australia NSW Liverpool
34 ULB ROUMEGUERE Thierry Belgium BRUXELLES-CAPITALE Bruxelles
35 Clinique St. Elisabeth GOEMINNE Jean-Charles Belgium N/A NAMUR
36 UCL DE MONT-GODINNE D'HONDT Lionel Belgium Yvoir Yvoir
37 复旦大学附属肿瘤医院 叶定伟 中国 上海 上海
38 Municipal medical institution “Makiivka City Hospital # 2, Donetsk region” KULYABA YAROSLAV Ukraine Makiivka Makiivka
39 Australian Clinical Trials - SAN Clinic WOO HENRY Australia NSW Wahroonga
40 Australian Urology Associates Pty Ltd FRYDENBERG MARK Australia Vic Malvern
41 A.Z. NIKOLAAS EVERAERT Els, M.D., Ph.D Belgium OOST-VLAANDEREN Sint-Niklaas
42 Clinique Notre Dame VERSCHAEVE VINCENT Belgium HENEGOUWEN Charleroi
43 Imelda ziekenhuis Wynendaele Wim Belgium N/A Bonheiden
44 ZNA Middelheim Schrijvers Dirk, M.D. Belgium N/A ANTWERPEN
45 Comité d'Ethique Hospitalo-Facultaire de Lièg WALTREGNY David Belgium N/A Liège
46 Clinique St Pierre WHENHAM Nicolas Belgium N/A Ottignies
47 AZ Klina DEMEY Wim, M.D Belgium N/A Brasschaat
48 CHC-Cliniques Saint-Joseph MATUS Geoffrey Belgium BRUXELLES-CAPITALE Liège
49 INSTITUTO DE ENSINO E PESQUISA SAO LUCAS PINCZOWSKI HELIO Brazil Sao Paulo Sao Paulo
50 HOSPITAL DE CARIDADE DE IJUI FRANKE FABIO Brazil RS IJUí
51 Instituto do cancer -COR -Hospital Mae de Deus AZAMBUJA ALAN Brazil RS Porto Alegre
52 INCA - Instituto Nacional Do Cancer HERCHENHORN DANIEL, MD Brazil RJ Rio De Janeiro
53 HOSPITAL SAO LUCAS - PUCRS VIOLA LUCIANA Brazil RS PORTO ALEGRE
54 Hospital Sao Jose CARVALHO RICARDO Brazil SP Sao Paulo
55 HOSPITAL DO SERVIDOR PUBLICO ESTADUAL Panhoca Renato Brazil SP Sao Paulo
56 Hospital Pedro Ernesto - UERJ DAMI?O RONALDO Brazil RJ Rio De Janeiro
57 Hospital Do Cancer De Barretos - Fundacao Pio Xii PEREIRA CAIO Brazil SP BARRETOS
58 INSTITUTO DO CANCER DO HOSPITAL POMPEIA DA ROSA VERONICA Brazil N/A CAXIAS DO SUL
59 INSTITUTO DE CANCER DE BRASILIA ARAUJO MAURICIO Brazil SP Ribeirao Preto
60 INSTITUTO DE CANCER DE BRASILIA GEHRKE JUNIA Brazil N/A BELO HORIZONTE
61 Hospital das Clinicas da Faculdade de Medicina da USP de Ribeirao Preto REIS RODOLFO Brazil N/A SAO PAULO
62 UNIVERSIDADE FEDERAL DE MINAS GERAIS GUIMARAES RODRIGO Brazil N/A SAO JOSE DO RIO PRETO
63 UNIVERSIDADE FEDERAL DE MINAS GERAIS SCALABRINI NETO ANTONIO ORLANDO Brazil N/A NOVO HAMBURGO
64 ICESP - INSTITUTO DO CANCER DO ESTADO DE SAO PAULO NAHAS WILLIAM CARLOS Brazil N/A SALVADOR
65 ICESP - INSTITUTO DO CANCER DO ESTADO DE SAO PAULO SANTANNA ALEXANDRE Brazil N/A SALVADOR
66 INSTITUTO SUL BRASILEIRO DE ONCOLOGIA RIGO RODRIGO Brazil RN NATAL
67 CIP - CENTRO INTEGRADO DE PESQUISA GIROTTO GUSTAVO Brazil SP Jau
68 ONCOSINOS FERREIRA FILHO ANTONIO Brazil Sao Paulo Sao Paulo
69 CENOB - CENTRO DE ONCOLOGIA DA BAHIA - ONCOVIDA NOGUEIRA ALBERTO Brazil RS IJUí
70 CLION - CLINICA DE ONCOLOGIA ANDRADE ANA CLEA Brazil RS Porto Alegre
71 LIGA NORTE RIOGRANDENSE CONTRA O CANCER GOMES ANDREA JULIANA Brazil RJ Rio De Janeiro
72 FUNDACAO HOSPITAL AMARAL CARVALHO CORADAZZI ANA LUCIA Brazil RS PORTO ALEGRE
73 Specialized Hospital for Active Treatment in Oncology Kurteva Galina Bulgaria N/A Sofia
74 Centre for Applied Urology Research Siemens, Robert Canada ON Kingston
75 BC Cancer Agency - Vancouver Clinic Chi, Kim Canada BC Vancouver
76 Cancer Care Manitoba Gingerich, Joel Canada MB WINNIPEG
77 Princess Margaret Hospital- UHN Fleshner, Neil Canada ON Toronto
78 CHUQ- L'Hotel-Dieu de Quebec Fradet, Yves Canada QC Quebec
79 The Ottawa Hosptial Cancer Centre Morgan, Scott Canada ON Ottawa
80 Cross Cancer Institute North, Scott Canada ALBERTA EDMONTON
81 Hopital Notre Dame Saad, Fred Canada QC Montreal
82 St. Josephs Healthcare Shayegan, Bobby Canada ON Hamilton
83 RS McLaughlin Durham Zalewski, Pawel Canada ON Oshawa
84 CENTRO DE ESPECIALIDADES MEDICAS UC DOMINGUEZ JAVIER Chile N/A Santiago
85 Hospital Dr Sotero del Rio PINOCHET RODRIGO Chile N/A Santiago
86 UROMED ORELLANA NELSON Chile N/A SANTIAGO
87 HOSPITAL PABLO TOBóN URIBE MARTINEZ CARLOS HUMBERTO Colombia ANTIOQUIA MEDELLIN
88 FOSCAL (Fund, Oftalm. Santander-Carlos Ardila Lulle) SALAZAR MILTON Colombia N/A FLORIDABLANCA
89 Clinica Universitaria Colombia LARIOS CARLOS Colombia Cundinamarca Bogota
90 Clínica del Country SOLANO SANTIAGO Colombia Cundinamarca Bogota
91 Vseobecna fakultni nemocnice v Praze - U nemocnice 2 Pavlik, Ivan Czech Republic Praha Praha 2
92 FN Hradec Kralove, Urologicka klinika Brodak, Milos Czech Republic N/A Hradec Kralove
93 Fakultni nemocnice Plzen, Urologicka klinika Hora, Milan Czech Republic N/A Plzen
94 Thomayerova nemocnice, Onkologicka klinika Buchler, Tomas Czech Republic N/A Praha 4
95 Aarhus University Hospital BORRE Michael Denmark N/A Aarhus
96 Regionshospitalet Holsterbro Urologic department JOHANSEN Jorgen Denmark N/A HOLSTERBRO
97 Vejle Hospital, Department of Oncology MEJLHOLM Inge Denmark N/A VEJLE
98 Odense University Hospital - SDR BOULEVARD 29 POULSEN Mads Denmark N/A Odense N/a
99 Roskilde Hospital department of urology WITTENDORF Hans-Erik Denmark N/A ROSKILDE
100 Tampere University Hospital Dept of Surgery Tammela, Teuvo Finland N/A TAMPERE
101 Oulu University Hospital Department of Urology Vaarala, Markku Finland N/A OULO
102 INSTITUT GUSTAVE ROUSSY FIZAZI karim France N/A Villejuif Cedex
103 HOPITAL ST JOSEPH DEPLANQUE GAEL France N/A Paris
104 HOPITAL HURIEZ VILLERS ARNAULD France N/A LILLE
105 POLYCLINIQUE DE BLOIS LAPLAIGE PHILIPPE France N/A La Chaussee St Victor
106 CLINIQUE BEAU SOLEIL ABDEL HAMID SAMER France N/A MONTPELLIER
107 HOPITAL FOCH THEODORE CHRISTINE France N/A Suresnes
108 HOPITAL RANGUEIL MALAVAUD BERNARD France N/A TOULOUSE
109 Urologikum Hamburg SUTTMANN HENRIK Germany Hamburg Hamburg
110 Universitaetsklinikum Duesseldorf Albers Peter Germany NRW DüSSELDORF
111 Martini-Klinik am UKE Hamburg Eppendorf - Germany LORCH ANJA Germany Hamburg HAMBURG
112 Studienpraxis Urologie Nürtingen - Germany FEYERABEND SUSAN Germany N/A Nürtingen
113 Churchill Hospital PROTHEROE ANDREW Great Britain N/A Oxford
114 Derriford Hospital NATALE SALVATORE Great Britain N/A Plymouth
115 Christie Hospital TRAN ANNA Great Britain N/A Manchester
116 Beatson West of Scotland Cancer Centre JONES ROB Great Britain LANARKSHIRE/Scotland Glasgow
117 Addenbrookes Hospital MAZHAR DANISH Great Britain Cambridgeshire Cambridge
118 Nottingham City Hospital NHS Trust MILLS JAMIE Great Britain England NOTTINGHAM
119 SEMMELWEIS EGYETEM, UROLOGIAI KLINIKA NYIRADY PETER Hungary N/A Budapest
120 URO-CLIN KFT Salamon Csaba Hungary N/A PECS
121 PETZ ALADAR MEGYEI OKTATO KORHAZ, UROLOGIA TORZSOK FERENC Hungary N/A Gyor
122 BAZ MEGYEI KORHAZ ES EGYETEMI OKTATO KORHAZ FEHER JOZSEF Hungary BORSOD-ABAUJ-ZEMPLEN Miskolc
123 ORSZAGOS ONKOLOGIAI INTEZET, C KEMOTERAPIAS OSZTALY GéCZI LAJOS Hungary N/A Budapest
124 Csongrád Megyei Dr Bugy István Kórház LAKATOS AKOS Hungary N/A Szentes
125 Meir Hospital KEIZMAN DANIEL Israel N/A Kfar Saba
126 Asaf Harofe Medical Center Sella Avishay Israel N/A Beer Yaakov
127 Hadassah Hospital FRANK STEPHEN Israel N/A Jerusalem
128 Rabin Medical Center ROSENBAUM ELI Israel N/A Petah-Tikva
129 Sheba Medical Center Tel Hashomer BERGER RAANAN Israel N/A Ramat Gan
130 Soroka Hospital Mermershtain Wilmosh Israel N/A Beer-Sheva
131 DIVISIONE DI ONCOLOGIA Oncology CARTENì GIACOMO Italy N/A Napoli
132 Rambam Hospital PEER AVIVIT Israel N/A Haifa
133 OSPEDALE S. DONATO - ASL 8 AREZZO Bracarda Sergio Italy N/A Arezzo
134 Istituto Oncologico Veneto - IRCCS BOCCARDO Francesco Italy PD Padova
135 Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori Conti Giario Italy N/A Meldola
136 Azienda Ospedaliera Universitaria Federico II DE PLACIDO Sabino Italy N/A Napoli
137 Istituto Nazionale dei Tumori di Napoli Fondazione G. Pascale Galli Luca Italy N/A Napoli
138 A.O.U. Pisana NICITA Giulio Italy N/A Pisa
139 Università degli Studi di Firenze SANTORO Armando Italy N/A Firenze
140 Isitituto Clinico Humanitas Sava Teodoro Italy Milano ROZZANO
141 Azienda Ospedaliera Universitaria Integrata Verona TONINI Giuseppe Italy N/A Verona
142 Università Campus Biomedico di Roma Ortega Cinzia Italy N/A Roma
143 Spedali Civili di Brescia FUKASAWA SATOSHI Italy N/A Brescia
144 Divisione di Oncologia - Istituto per la ricerca e cura del cancro SUZUKI HIROYOSHI Italy N/A Candiolo
145 Chiba Cancer Center MATSUBARA NOBUAKI Japan N/A Chiba
146 Toho University Sakura Medical Center UEMURA HIROJI Japan N/A Sakura
147 National Cancer Center Hospital East Tsuchiya Tomohiro Japan N/A Kashiwa
148 Yokohama City University Hospital UEMURA HIROTSUGU Japan N/A Yokohama
149 Gifu University Hospital KANAYAMA HIROOMI Japan N/A Gifu
150 Kinki University Hospital HASHINE KATSUYOSHI Japan N/A Osaka-Sayama
151 Tokushima University Hospital SATO FUMINORI Japan N/A Tokushima
152 National Shikoku Cancer Center HARA TAKAHIKO Japan N/A Matsuyama
153 Oita University Hospital MATSUMOTO HIROAKI Japan N/A Yufu
154 Yamaguchi University Hospital OYA MOTOTSUGU Japan N/A Ube
155 Keio University Hospital SHUIN TARO Japan N/A Shinjuku
156 Asan Medical Center Lee Jae-Lyun Korea N/A Seoul
157 Samsung Medical Center Park Se Hoon Korea N/A Seoul
158 Korea University Anam Hospital Kim YeulHong Korea N/A Seoul
159 Kyungpook National University Medical Center Kang, ByungWoog Korea N/A Daegu
160 National Cancer Center Lee, KangHyun Korea N/A Gyeonggi-do
161 Soonchunhyang University Bucheon Hospital Kim, ChanKyu Korea N/A Gyeonggi-Do
162 Inje University Busan Paik Hospital Kim KiHyang Korea N/A Busan
163 Chungnam National University hospital Yun Hwan Jung Korea N/A Daejeon
164 Seoul National University Hospital LEE SE-HOON Korea N/A Seoul
165 University Malaya Medical Centre Saad Marniza Malaysia Wilayah Persekutuan Kuala Lump Kuala Lumpur
166 Hospital Kuala Lumpur Sundram Murali Malaysia Wilayah Persekutuan Kuala Lump Kuala Lumpur
167 Consultorio de Especialidad en Urologia Privado Lei Clarence Mexico Durango Durango
168 CENTRO ONCOLOGICO BELENUS Calvo David Mexico Morelos Cuernavaca
169 Oaxaca Site Management Organization S.C. TELLO JOSE MANUEL Mexico Oaxaca Oaxaca
170 UNIDAD DE INVESTIGACION EN SALUD HERNANDEZ CARLOS Mexico Chihuahua Chihuahua
171 Hospital Universitario Dr. Jose Eleuterio Gonzalez GONZALEZ RENE Mexico Nuevo Leon Monterrey
172 Investigacion Biomedica Aplicada de Hidalgo S.A. de C.V. Moreno Ruben Mexico Hidalgo Pachuca de Soto
173 Consultorio Privado Rodriguez Jose Arturo Mexico Jalisco Zapopan
174 Centro de Investigacion y Atencion Integral Durango S.C. Reyes Francisco Mexico Durango Durango
175 Spaarne Ziekenhuis BEEKER A. Netherlands Noord-Holland Hoofddorp
176 ZIEKENHUIS HILVERSUM van den Berg H.P. Netherlands NOORD-HOLLAND Hilversum
177 Prostaatcentrum zuidwest Nederland BUSSTRA Martijn Netherlands ZUID-HOLLAND Rotterdam
178 AMC DE LA ROSETTE Jean Netherlands N/A AMSTERDAM ZUIDOOST
179 VU Medisch Centrum VAN MOORSELAAR R.J.A. Netherlands N/A AMSTERDAM
180 Sint Antonius Ziekenhuis - Afd.Interne - INT HUNTING J.C.B. Netherlands N/A NIEUWEGEIN
181 Medisch Centrum Alkmaar Hendriks M.P Netherlands N/A ALKMAAR
182 Canterbury Urology Research Trust Kueppers Frank Netherlands N/A Christchurch
183 Tauranga Urology Research Limited Gilling Peter New Zealand N/A Tauranga
184 North Shore Hospital Beaven Anthony New Zealand Auckland Auckland
185 Urology Waikato Ltd Holmes Michael New Zealand Waikato Hamilton
186 Uniwersyteckie Centrum Kliniczne Jassem Jacek Poland N/A Gdansk
187 Specjalistyczne Gabinety Lekarskie Oszukowska Elzbieta Poland N/A Lodz
188 Wojewodzki Szpital Specjalistyczny w Lublinie Niezabitowski Jacek Poland N/A Lublin
189 Centrum Onkologii - Instytut im. M. Sklodowskiej-Curie Sikora-Kupis Bozena Poland N/A Warszawa
190 Szpital Sw. Elzbiety Chwalinski Maciej Poland N/A Warszawa
191 10 Wojskowy Szpital Kliniczny z Poliklinika, Samodzielny Zaklad Opieki Zdrowotnej Swiniarski Piotr Poland N/A Bydgoszcz
192 Hospital S. Joao SILVA CARLOS Portugal N/A Porto
193 Instituto Português de Oncologia Francisco Gentil - Centro Regional de Oncologia de Coimbra, S.A. CONCEICAO PAULO Portugal N/A Coimbra
194 Hospital Geral de Santo Antonio Fraga Avelino Portugal N/A Porto
195 Hospital da Luz Rodrigues Tania Portugal N/A Lisboa
196 Instituto Portugues de Oncologia Maurício Joaquina Portugal N/A Porto
197 CENTRO HOSPITALAR DE LISBOA CENTRAL PINHEIRO LUIS Portugal N/A LISBOA
198 Hospital de Braga Lima Estevao Portugal N/A Braga
199 HOSPITAL DE SANTA MARIA PALMA DOS REIS JOSE Portugal N/A LISBOA
200 Centrul de Oncologie-Euroclinic SRL VOLOVAT CONSTANTIN Romania N/A IASI
201 Spitalul Clinic de Urologie Prof. Dr. Theodor Burghele Jinga Viorel Romania N/A Bucharest
202 Institutul Clinic Fundeni Harza Mihai Romania N/A Bucuresti
203 Hertzen Oncology Research Institute Alexeev, Boris Russia N/A Moscow
204 Clinical diagnostical center Alyasova, Anna Russia N/A Nizhny Novgorod
205 State Budgetary Institution of Rostov region Budnik, Nikolay Russia N/A Rostov on Don
206 Russian Research Center of Roentgenology & Radiology under the Federal Agency for Healthcare and Soc Ivanov, Sergey Russia N/A Moscow
207 State Educational Istitution Izmailov, Adel Russia N/A Ufa
208 State Medical Institution Khvorostenko, Denis Russia N/A St.-Petersburg
209 Cancer Research Center Matveev, Vsevolod Russia N/A Moscow
210 Scientific Research Institute of Oncology n.a. Prof. N.N. Petrov Nosov, Alexander Russia N/A St.-Petersburg
211 GBUZ of Stavropol region Pyatigorsk Oncological Dispensary Vladimirov, Vladimir Russia N/A Pyatigorsk
212 Sverdlovsk Region Clinical Hospital #1 Zyryanov, Alexander Russia N/A Ekaterinburg
213 Volgograd Region Oncology Dispensary Sheveleva, Lyudmila Russia N/A Volgograd
214 Russian Cancer Research Center Bulanov, Anatoly Russia N/A Moscow
215 Ivanovo Regional Oncology Dispensary Semenov, Andrey Russia N/A Ivanovo
216 Chelyabinsk Regiona Onc. Center Gladkov, Oleg Russia N/A Chelyabinsk
217 Ryazan Regional Clinical Oncology Dispensary Kulikov, Evgeny Russia N/A Ryazan
218 Republican Clinical Oncology Dispensary Emelyanov, Sergey Russia N/A Izhevsk
219 Medical Radiological Research Center Karyakin, Oleg Russia N/A Obninsk, Kaluga Region
220 GBUZ 'Orenburg Regional Oncology Dispensary' Shirinkin, Vadim Russia N/A Orenburg
221 Russian Scientific Center of Radiology and Surgical Technologies Shkolnik, Mikhail Russia N/A Leningrad Region
222 Regional Oncological Dispansery Lykov, Alexander Russia N/A Tumen
223 Ogarev Mordovian State University Skopin, Pavel Russia N/A Saransk
224 Regional Oncology Dispansery #2 Andreyashkina, Irina Russia N/A Saratov
225 Omsk Regional Clinical Hospital Kopyltsov, Evgeny Russia N/A Omsk
226 Fakultna nemocnica Trnava Mikurcik Erich Slovakia N/A Trnava
227 Nemocnica Kosice-Saca Milichovsky Igor Slovakia N/A Kosice-saca
228 Urologická ambulancia Mir Obaidullah Slovakia N/A Rimavska Sobota
229 Urologicka ambulancia Gajdos Milan Slovakia N/A Piestany
230 Univerzitná nemocnica Martin Kliment Jan Slovakia N/A Martin
231 MILAB s.r.o. Mincik Ivan Slovakia N/A Presov
232 Langenhoven Drive Oncology Malan Jorn R South Africa Eastern Cape Port Elizabeth
233 Dr J Bahlmann Bahlmann Johann CM South Africa Western Cape George
234 Prinshof Medical Campus Moshokoa Evelyn South Africa N/A Pretoria
235 East Rand Urology Research Unit Madlala Thamsanqa SL South Africa Gauteng Vosloorus
236 Urology Hospital Coetzee Lance JE South Africa Gauteng Pretoria
237 HOSPITAL CLINIC I PROVINCIAL Ribal Maria Jose Spain Barcelona Barcelona
238 HOSPITAL GREGORIO MARANON HERNANDEZ FERNANDEZ CARLOS Spain Madrid Madrid
239 Hospital General Universitario Morales Meseguer Minana Bernardino Spain N/A Murcia N/a
240 HOSPITAL JUAN CANALEJO Martínez Breijo Sara Spain A Coruna Coruna
241 HOSPITAL PUERTA DE HIERRO Carballido Joaquin Spain Majadahonda Madrid
242 Centro Integral Oncológico Clara Campal OLMOS DAVID Spain Madrid Sanchinarro
243 Hospital Universitario Reina Sofia Requena Ma José Spain CORDOBA Cordoba
244 Hospital 12 de Octubre Rodríguez Antolín Alfredo Spain N/A Madrid
245 Hospital Universitario Vall d′Hebron Morote Juan Spain N/A Barcelona
246 Urologmottagningen SU/Sahlgrenska DAMBER Jan-Erik Sweden N/A GOTEBORG
247 Urologiska kliniken HAGGMAN Michael Sweden N/A UPPSALA
248 Urologiska kliniken S?S NYMAN Claes Sweden N/A STOCKHOLM
249 Norrlands Universitetssjukhus, Urologiska Kliniken, Umea HUGOSSON Jonas Sweden N/A Umea
250 Skanes Universitetssjukhus LJUNGBERG Borje Sweden N/A MALMO
251 HACETTEPE UNI MEDICAL FACULTY DEPT. OF UROLOGY Ozen, Haluk Turkey N/A ANKARA
252 ANKARA UNI. MEDICAL FACULTY IBN-I SINA HOSPITAL DEPT. OF UROLOGY BEDUK YASAR Turkey N/A ANKARA
253 GAZI UNIVERSITY MEDICAL FACULTY HOSPITAL DEPARTMENT OF UROLOGY Sozen, Sinan Turkey N/A ANKARA
254 ANKARA NUMUNE EGITIM VE ARASTIRMA HASTANESI 2. UROLOJI KLINIGI CETINKAYA MESUT Turkey N/A ANKARA
255 ISTANBUL UNIVERSITESI CERRAHPASA TIP FAKULTESI IC HASTALIKLARI ANABILIM DALI MEDIKAL ONKOLOJI BD Ozguroglu, Mustafa Turkey N/A ISTANBUL
256 MARMARA UNIVERSITESI TIP FAKULTESI PENDIK EGITIM VE ARASTIRMA HASTANESI Tinay, Ilker Turkey N/A ISTANBUL
257 EGE UNIVERSITESI TIP FAKULTESI Ozyurt, Mehmet Ceyhun Turkey N/A IZMIR
258 CUKUROVA UNIVERSITESI TIP FAKULTESI Tansug, Zuhtu Turkey N/A ADANA
259 BULENT ECEVT UNIVERSITESI TIP FAKULTESI HASTANESI Mungan, Aydin Turkey N/A ZONGULDAK
260 Istanbul Egitim ve Arastirma Hastanesi Toktas, Gokhan Turkey N/A Istanbul
261 Uzhgorod Cenrtal City Hospital, city oncology center HOTKO EUGENE Ukraine N/A Uzhgorod
262 DNIPROPETROVSK STATE CLINICAL HOSPITAL NA MECHNIKOV I.I., Urology department #2 STUS VIKTOR Ukraine N/A DNIPROPETROVSK
263 REGIONAL CLINICAL CENTER OF UROLOGY AND NEFROLOGY NA SHAPOVALOV V.I. KHAREBA GENNADII Ukraine N/A KHARKIV
264 Municipal Institution LYULKO OLEKSIY Ukraine N/A Zaporizhzhia
265 KHARKOV REGIONAL CLINICAL ONCOLOGY DISPENSARY VINNYK YURIY Ukraine N/A KHARKOV
266 Lviv State Regional Oncology Medical and Diagnostic Center, chemotherapy department SHPARYK YAROSLAV Ukraine N/A Lviv
267 State Institution SAKALO VALERII Ukraine N/A Kyiv
268 Dnepropetrovsk State Medical Academy - Department of Oncology BONDARENKO IGOR Ukraine N/A Dnepropetrovsk
269 Cherkassy Regional Oncology Dispensary, chemotherapy department PARAMONOV VIKTOR Ukraine N/A Cherkassy
270 City clinical hospital # 10, department of Urology HODOS VALERIY Ukraine N/A Odessa
271 Municipal medical institution “Makiivka City Hospital # 2, Donetsk region” KULYABA YAROSLAV Ukraine N/A Makiivka

  


  

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